Allografts can be rejected as a result of major histocompatibility antigen disparity or as a
result of differences at any of a number of minor histocompatibility antigens. In many cases,
rejection due to multiple minor histoincompatibility is as difficult to control as that induced by
major histoincompatibility. Although an understanding of the molecular, biochemical, and
functional parameters of the major histocompatibility loci and their products is increasing at
an exponential rate, little is known about these same facets of minor histocompatibility loci …